2001 TSSAA Division I Class A State Softball Tournament
| Seeding | May 14 Regional Semi-Finals |
May 16 Regional Finals |
May 18 Sectional |
May 22-26 State | |||
| (H) Dist. 1 W | Unaka | ||||||
| ¦ | Unaka 17 | ||||||
| Dist. 2 R-Up | Powell Valley | ¦ | ¦ | ||||
| ¦ | Unaka 1 | ||||||
| (H) Dist. 2 W | Jellico 9 | ¦ | ¦ | ||||
| ¦ | Hampton 3 | ¦ | ¦ | Rockwood | |||
| Dist. 1 R-Up | Hampton 12 | ¦ | ¦ | ||||
| Rockwood 4 | ¦ | ||||||
| (H) Dist. 3 W | Cosby 6 | ||||||
| ¦ | Cosby 8 | ||||||
| Dist. 4 R-Up | Oakdale 1 | ¦ | ¦ | ||||
| ¦ | Cosby 11 | ||||||
| (H) Dist. 4 W | Rockwood | ¦ | ¦ | ||||
| ¦ | Rockwood 2 | ¦ | ¦ | Cosby | |||
| Dist. 3 R-Up | Alcoa | ¦ | ¦ | ||||
| Hampton 1 | ¦ | ||||||
| (H) Dist. 5 W | Boyd Buchanan | ||||||
| ¦ | Boyd Buchanan 5 | ||||||
| Dist. 6 R-Up | Whitwell | ¦ | ¦ | ||||
| ¦ | Boyd Buchanan 8 | ||||||
| (H) Dist. 6 W | Chatt. Christian 6 | ¦ | ¦ | ||||
| ¦ | Chatt. Chr. 0 | ¦ | ¦ | Boyd Buchanan | |||
| Dist. 5 R-Up | Grace 5 | ¦ | ¦ | ||||
| Watertown 3 | ¦ | ||||||
| (H) Dist. 7 W | Red Boiling Spr. 2 | ||||||
| ¦ | Watertown 0 | ||||||
| Dist. 8 R-Up | Watertown 5 | ¦ | ¦ | ||||
| ¦ | Friendship Chr. 4 | ||||||
| (H) Dist. 8 W | Friendship Chr. 15 | ¦ | ¦ | ||||
| ¦ | Friendship Chr. 10 | ¦ | ¦ | Friendship Chr. | |||
| Dist. 7 R-Up | Hermitage Spr. 0 | ¦ | ¦ | ||||
| Chatt. Chr. 2 | ¦ | ||||||
| (H) Dist. 9 W | Ezell Harding 2 | ||||||
| ¦ | Ezell Harding 2 | ||||||
| Dist. 10 R-Up | McEwen 0 | ¦ | ¦ | ||||
| ¦ | Ezell Harding 11 | ||||||
| (H) Dist. 10 W | Davidson Aca. 0 | ¦ | ¦ | ||||
| ¦ | Goodpasture 0 | ¦ | ¦ | Ezell Harding | |||
| Dist. 9 R-Up | Goodpasture 1 | ¦ | ¦ | ||||
| Columbia Aca. 1 | ¦ | ||||||
| (H) Dist. 11 W | Forrest | ||||||
| ¦ | Forrest | ||||||
| Dist. 12 R-Up | Summertown | ¦ | ¦ | ||||
| ¦ | Forrest 0 | ||||||
| (H) Dist. 12 W | Columbia Aca. 3 | ¦ | ¦ | ||||
| ¦ | Columbia Aca. | ¦ | ¦ | Goodpasture | |||
| Dist. 11 R-Up | Cornersville 0 | ¦ | ¦ | ||||
| Goodpasture 4 | ¦ | ||||||
| (H) Dist. 13 W | Huntingdon 3 | ||||||
| ¦ | Adamsville 8 | ||||||
| Dist. 14 R-Up | Adamsville 10 | ¦ | ¦ | ||||
| ¦ | Adamsville 13 | ||||||
| (H) Dist. 14 W | Jackson Chr. | ¦ | ¦ | ||||
| ¦ | Jackson Chr. 6 | ¦ | ¦ | Adamsville | |||
| Dist. 13 R-Up | West Carroll | ¦ | ¦ | ||||
| Peabody 1 | ¦ | ||||||
| (H) Dist. 15 W | South Fulton 2 | ||||||
| ¦ | South Fulton 9 | ||||||
| Dist. 16 R-Up | Halls 0 | ¦ | ¦ | ||||
| ¦ | South Fulton 2 | ||||||
| (H) Dist. 16 W | Peabody 12 | ¦ | ¦ | ||||
| ¦ | Peabody 0 | ¦ | ¦ | South Fulton | |||
| Dist. 15 R-Up | Dresden 2 | ¦ | ¦ | ||||
| Jackson Chr. 1 | ¦ |
If a district winner from a district that is to host the regional finals is defeated, the district runner-up from that district shall host the regional finals. (Example: If it is district 2's time to host the region and the district 2 winner is defeated, the district 2 runner-up (provided that team wins) shall host the regional finals. If both teams from district are defeated in the regional semi-final games, the district 1 winner shall host the regional finals.)