| Date | Time | Opponent | Location | Comment |
| 08/27/2010 (Fri) | 7:00 pm | Christian Brothers High School | Away | |
| 09/03/2010 (Fri) | 7:00 pm | Collierville High School * | Away | |
| 09/10/2010 (Fri) | 7:00 pm | Hamilton High School | Home | |
| 09/17/2010 (Fri) | 7:00 pm | Houston High School * | Home | |
| 09/24/2010 (Fri) | 7:00 pm | Kingsbury High School | Home | Homecoming |
| 10/01/2010 (Fri) | 7:00 pm | Kirby High School * | Home | |
| 10/08/2010 (Fri) | 7:00 pm | Southwind High School * | Away | |
| 10/15/2010 (Fri) | 7:00 pm | Wooddale High School * | Home | |
| 10/22/2010 (Fri) | 7:00 pm | Ridgeway High School * | Away | |
| 10/29/2010 (Fri) | 7:00 pm | Overton High School * | Home | Senior Night |